O-phenylphenol

Our Factory
Xingbang (Shandong) New Materials Technology Co., Ltd. Was established in 2006 and is located in Wenshang Chemical Industrial Park with a registered capital of 50.07 million yuan. It is dedicated to the manufacturing of special chemical products. It is a technology-based enterprise integrating scientific research, design and production. , through more than ten years of continuous efforts, the company has developed rapidly and healthily, and has been engaged in related fields for 16 years. It is a fine chemical enterprise integrating R&D, production and sales.

Our Product
The company's flagship product, o-phenylphenol (OPP), is a very important new fine chemical and chemical intermediate with a wide range of applications.

Product Application
The synthesis of new phosphorus-containing flame retardant materials is becoming more and more widely used and will gradually replace the inorganic and halogen-containing flame retardant materials used today. They are widely used in adhesives, electronic instruments, aerospace, 5G communication equipment, coatings and advanced composite materials. and other fields.
Synthetic optical film material oppea is widely used in composite material matrix, insulation materials, adhesives and optical coating materials and other fields, and has broad application prospects.
Antiseptic and sterilizing, it has broad-spectrum sterilization and mildew removal capabilities, and is non-toxic and odorless. It is a good preservative; it can be used as a dyeing carrier for synthetic fibers; it can also be used to synthesize developers for pressure-sensitive and heat-sensitive papers.

Our Certificate
The company develops new technologies and products to enhance the company's comprehensive strength. It has obtained 2 invention patents through independent research and development, and is applying for 15 utility model patents. The use of intellectual property rights has significantly improved the technological content of its products, especially " The use of the invention patent "a scraper evaporator" allows the product to be recovered after condensation, and the selectivity of the prepared o-phenylphenol reaches 94%.

The primary use of Ortho phenyl phenol is as an agricultural fungicide.
Ortho phenyl phenol is generally applied post-harvest.
Ortho phenyl phenol is a fungicide used for waxing citrus fruits.
Ortho phenyl phenol is no longer a permitted food additive in the European Union, but is still allowed as a post-harvest treatment in 4 EU countries.

Ortho phenyl phenol is also used for disinfection of seed boxes.
Ortho phenyl phenol is a general surface disinfectant, used in households, hospitals, nursing homes, farms, laundries, barber shops, and food processing plants.

Ortho phenyl phenol can be used on fibers and other materials.
Ortho phenyl phenol is used to disinfect hospital and veterinary equipment.
Other uses are in rubber industry and as a laboratory reagent.

Ortho phenyl phenol is also used in the manufacture of other fungicides, dye stuffs, resins and rubber chemicals.
Ortho phenyl phenol is found in low concentrations in some household products such as spray disinfectants and aerosol or spray underarm deodorants.

The sodium salt of orthophenyl phenol, sodium orthophenyl phenol, is a preservative, used to treat the surface of citrus fruits.
Ortho phenyl phenol is also used as a fungicide in food packaging and may migrate into the contents.

The primary use of Ortho phenyl phenol is as an agricultural fungicide.
Ortho phenyl phenol is generally applied post-harvest.
Ortho phenyl phenol is a fungicide used for waxing citrus fruits.
As a food additive, it has E number E231.

Ortho phenyl phenol is also used for disinfection of seed boxes.
Ortho phenyl phenol is a general surface disinfectant, used in households, hospitals, nursing homes, farms, laundries, barber shops, and food processing plants.
Ortho phenyl phenol can be used on fibers and other materials.

Ortho phenyl phenol is used to sterilize hospital and veterinary equipment.
Other uses are in rubber industry and as a laboratory reagent.
Ortho phenyl phenol is also used in the manufacture of other fungicides, dye stuffs, resins and rubber chemicals.

Ortho phenyl phenol is found in low concentrations in some household products such as spray disinfectants and aerosol or spray underarm deodorants.
Eye contact can cause severe irritation and burns with possible eye damage.
For some individuals, Ortho phenyl phenol can also irritate the skin.

The sodium salt of orthophenyl phenol, sodium orthophenyl phenol, is a preservative, used to treat the surface of citrus fruits to prolong shelf life.
As a food additive, it has the E number E232.

Ortho phenyl phenol is remarkably versatile organic chemical products, widely used antiseptic, auxiliaries and surfactant synthesis of new plastics, resins and polymer materials in areas such as stabilizers and flame retardants.

Accurately weigh about 2g of powdered o-phenylphenol sample, add 25ml of sodium hydroxide test solution (TS-224), and dissolve it by warming if necessary. After cooling, add water to 500ml to use as the sample solution. Take 25ml of this sample solution and transfer it into an iodine bottle, accurately add 30ml of 0.1mol/L potassium bromate solution, then add 5ml of potassium bromide test solution (TS-181) and 50ml of methanol, and shake it thoroughly. Quickly add about 10ml of 1:1 dilute hydrochloric acid, stopper it immediately, shake it gently, and react for 30s.
Take 15ml of potassium iodide test solution (TS-19Chemicalbook2), place it on the top of the iodine bottle, loosen the stopper to let it flow in, rinse the stopper and bottle mouth with water, shake it thoroughly, and leave it for 5min. Titrate the free iodine with 0.1mol/L sodium thiosulfate solution, and use starch test solution (TS-235) as an indicator. Perform a blank test using the same method and calculate the content according to the following formula. Content (%) = 4.255 × (a-b) / sample amount (g) × 50 × 100% where a is the volume of sodium thiosulfate consumed in blank, m1; b is the volume of sodium thiosulfate consumed in sample solution, ml.

O-Phenylphenol (OPP) and its salts, SOPP and POPP, are preservatives in cosmetics, preventing microbial growth to extend shelf life and ensure safety.
The Scientific Committee on Consumer Safety (SCCS) has recently published an extensive report on the safety of o-Phenylphenol (OPP), Sodium o-Phenylphenate (SOPP), and Potassium o-Phenylphenate (POPP) when used as preservatives in cosmetic products. This thorough review comes in response to growing regulatory scrutiny and public concern regarding the potential health risks associated with these chemical compounds. The report aims to provide a detailed risk assessment, offering guidance for both regulatory bodies and cosmetic manufacturers.

Findings on Dermal Absorption
A significant area covered in the report is the dermal absorption of OPP. Multiple studies indicate that OPP is rapidly absorbed through human skin, with an absorption rate of approximately 43%. This finding is critical as it highlights the efficiency of skin absorption and the subsequent excretion process. The majority of the absorbed substance is excreted through urine within the first 24 hours, effectively minimising the risk of systemic accumulation. The rapid excretion is further supported by studies involving human volunteers where radiolabelled OPP was applied topically. The results showed that most of the absorbed dose was recovered in the urine, underscoring the body's ability to eliminate OPP efficiently.

Detailed Toxicological Evaluation
The report includes a comprehensive toxicological evaluation of OPP and its salts, focusing on several key aspects.

Irritation and Corrosivity
The studies reviewed in the report demonstrate that OPP and its salts can cause significant skin and eye irritation. The undiluted forms of these compounds are particularly concerning, as they can be highly irritating or even corrosive to the skin and eyes. This highlights the importance of using these substances in controlled concentrations to avoid adverse effects.

Skin Sensitisation
The potential for skin sensitisation is another crucial aspect of the toxicological evaluation. The SCCS report concludes that OPP and its salts have a low potential for skin sensitisation. This conclusion is based on animal studies that, despite some deviations from OECD guidelines, showed no significant sensitisation potential. Furthermore, human studies indicate a low frequency of sensitisation, primarily observed in occupational settings rather than general cosmetic use. This suggests that, under normal usage conditions, the risk of skin sensitisation from OPP is minimal.

Carcinogenicity
Chronic toxicity and carcinogenicity studies have identified the urinary bladder and kidneys as primary target tissues for OPP and SOPP in mice and rats. The mode of action for bladder carcinogenesis is thought to involve chronic irritation of the epithelium due to factors such as high urinary pH and the presence of free metabolites. These findings are critical for understanding the long-term risks associated with exposure to these compounds.

Safety and Regulatory Recommendations
Based on the findings of the report, the SCCS concludes that OPP is safe for use as a preservative in cosmetic products up to a maximum concentration of 0.2% in rinse-off products and 0.15% in leave-on products. This safety assessment also applies to the combined use of OPP and SOPP, which should not exceed these concentrations in cosmetic formulations. The detailed recommendations provided by the SCCS are intended to guide manufacturers in formulating safe cosmetic products and help regulatory bodies enforce appropriate safety standards.

While certain risks such as skin irritation and potential carcinogenicity in specific contexts are noted, the controlled use of these compounds within specified concentration limits is deemed safe for consumers.
Ensuring the safe formulation and use of preservatives in cosmetic products. By following the SCCS's guidance, the industry can continue to provide safe and effective products to consumers, maintaining public trust and compliance with regulatory standards.